Feasibility of Using Plasma Rather Than Serum in First and Second Trimester Multiple Marker Down's Syndrome Screening
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چکیده
منابع مشابه
ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome.
BACKGROUND ADAM 12 is a placenta-derived glycoprotein that is involved in growth and differentiation. The maternal serum concentration of ADAM 12 is a potential first-trimester maternal serum marker of Down syndrome (DS). Here we examine the potential of ADAM 12 as a second-trimester maternal serum marker of DS. MATERIALS AND METHODS The concentration of ADAM 12 was determined in gestational ...
متن کاملSecond trimester maternal dimeric inhibin-A in the multiple-marker screening test for Down's syndrome.
The aim of this study was to evaluate the additional value of dimeric inhibin-A serum concentration in second trimester multiple-marker screening tests for pregnancies affected by Down's syndrome. We anticipated that second trimester maternal serum dimeric inhibin-A concentrations would be altered in pregnancies complicated by fetal Down's syndrome and that dimeric inhibin-A would perform bette...
متن کاملADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.
BACKGROUND A Disintegrin And Metalloprotease 12 (ADAM 12) is a glycoprotein synthesised by placenta and it has been shown to be a potential first-trimester maternal serum marker for Down syndrome (DS) in two small series. Here we analyse further, the potential of ADAM 12 as a marker for DS in a large collection of first-trimester serum samples. MATERIALS AND METHODS The concentration of ADAM ...
متن کاملSecond-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening.
Immunosuppressive Drug Monitoring. Ther Drug Monit 2002;24:59–67. 12. Novartis. Neoral C-2 monitoring: scientific evidence and clinical validation. http://www.transplantation-schweiz.ch/e/sandimmun/Scientific_Monograph. pdf (accessed June 2004). 13. Morris RG, Russ GR, Cervelli MJ, Juneja R, McDonal SP, Mathew TH. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclo...
متن کاملFirst and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS).
The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and combinations of markers together with maternal age was assessed using standard methods. In addition pairs of first and second trimester serum samples from 600 controls were tested to secure a larger ...
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ژورنال
عنوان ژورنال: Journal of Medical Screening
سال: 2012
ISSN: 0969-1413,1475-5793
DOI: 10.1258/jms.2012.012086